An Update on New Anticoagulants

Author(s): Lori-Ann Linkins, Jeffrey I. Weitz.

Journal Name:Current Drug Targets - Cardiovascular & Hematological Disorders

Volume 3 , Issue 4 , 2003

Abstract:

A variety of new anticoagulants for the prevention and treatment of venous and arterial thromboembolism are under development. Designed to overcome the limitations of heparin and vitamin K antagonists, these new agents are at various stages of clinical testing. This paper reviews venous and arterial thrombogenesis, discusses the regulation of coagulation, identifies the molecular targets for new anticoagulants, describes new anticoagulants in more advanced stages of clinical testing, and provides perspective on how these agents will impact on practice.

Keywords: anticoagulants, thromboembolism, heparin, vitamin k antagonists, thrombogenesis, coagulation

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Article Details

VOLUME: 3
ISSUE: 4
Year: 2003
Page: [287 - 300]
Pages: 14
DOI: 10.2174/1568006033481366
Price: $58