Current Medicinal Chemistry - Central Nervous System Agents


Serotonin Type-4 (5-HT4) Receptors as Therapeutic Targets: 5-HT4 Receptor Antagonists

Author(s): Henri Mattes, Hans-Juergen Pfannkuche.


Characterization of 5-HT 4 receptors started in the late eighties following the important finding that the potent 5-HT3 receptor antagonist, tropisetron, could act as a competitive antagonist at the newly discovered 5-HT4 receptor. During recent years several pharmaceutical companies claimed that their 5-HT4 antagonists might be useful for the treatment and / or prophylaxis of cardiovascular, CNS and gastrointestinal disorders. This paper reviews the development of 5-HT4 receptor antagonists from experimental tools towards potential therapeutic agents.

Keywords: 5-ht4 receptor, 5-ht4 receptor antagonist, serotonin antagonist

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Year: 2003
Page: [37 - 42]
Pages: 6
DOI: 10.2174/1568015033357742