Current Medicinal Chemistry - Anti-Cancer Agents

Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Biological Targets of Antitumor Indolocarbazoles Bearing a Sugar Moiety

Author(s): Michelle Prudhomme.

Abstract:

Natural and synthetic indolocarbazole compounds have triggered considerable interest since the discovery in 1986 of the inhibitory properties of staurosporine toward protein kinase C (PKC). Later, it has been shown that indolocarbazole compounds may inhibit various kinases, such as cyclin dependent-kinases and / or topoisomerase I, someones behave only as DNA intercalators. In this review are presented various indolocarbazole compounds bearing a sugar moiety and their biological targets. The relevance of these targets to develop indolocarbazole compounds as potential antitumor agents is discussed.

Keywords: indolocarbazoles, protein kinases, topoisomerase I, dna intercalators, antitumor agents

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Article Details

VOLUME: 4
ISSUE: 6
Year: 2004
Page: [509 - 521]
Pages: 13
DOI: 10.2174/1568011043352650
Price: $58