Current Medicinal Chemistry-Anti-Cancer Agents

Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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G-Quadruplex Interacting Agents Targeting the Telomeric G-Overhang Are More than Simple Telomerase Inhibitors

Author(s): Jean-Francois Riou.

Abstract:

The extremities of chromosomes end at telomeres in a G-rich single stranded overhang that may adopt peculiar structures such as T-loop and G-quadruplex. G-quadruplex is a poor substrate for telomerase activity and different classes of small molecule ligands that selectively stabilize this structure and inhibit telomerase activity have been selected by screening or synthesized by oriented chemistry. These ligands differ from catalytic inhibitors of telomerase by several points that were discussed in the present review, with a special emphasis on their biological activity as potential antitumor agents.

Keywords: g-quadruplex interacting Agents, telomeric g-overhang, telomerase inhibitors, g-quadruplex, telomerase

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Article Details

VOLUME: 4
ISSUE: 5
Year: 2004
Page: [439 - 443]
Pages: 5
DOI: 10.2174/1568011043352740
Price: $58