Current Medicinal Chemistry - Anti-Cancer Agents

Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex


Combining DNA Damaging Agents and Checkpoint 1 Inhibitors

Author(s): Michelle Prudhomme.


During the cell cycle that leads to mitosis, checkpoints are activated in response to DNA damage. The checkpoints control the ability of cells to arrest the cell cycle allowing time to repair the DNA. In more than 50% of cancer cells, the G1 checkpoint is inactive due to mutations of p53. Therefore, the combination of a DNA damaging agent with a G2 checkpoint inhibitor should force selectively cancer cells into a premature and lethal mitosis. This approach which has recently drawn considerable interest is discussed in this paper.

Keywords: dna damaging agents, checkpoint 1 inhibitors, g2 checkpoint inhibitor, mitosis

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Article Details

Year: 2004
Page: [435 - 438]
Pages: 4
DOI: 10.2174/1568011043352795
Price: $58