Current Medicinal Chemistry - Anti-Cancer Agents

Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Antifolates - Past, Present and Future

Author(s): Aleem Gangjee, Hiteshkumar D. Jain.

Abstract:

This short perspective briefly covers selected aspects of the past, present and future of antifolates in chemotherapy. Both classical and nonclassical analogs currently in the preclinical stage and clinically used agents are covered.

Keywords: thymidylate synthase (ts), dihydrofolate reductase (dhfr), antifolates, classical, nonclassical, inhibitors

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Article Details

VOLUME: 4
ISSUE: 5
Year: 2004
Page: [405 - 410]
Pages: 6
DOI: 10.2174/1568011043352803
Price: $58