Antifolates - Past, Present and Future
Hiteshkumar D. Jain.
This short perspective briefly covers selected aspects of the past, present and future of antifolates in chemotherapy. Both classical and nonclassical analogs currently in the preclinical stage and clinically used agents are covered.
Keywords: thymidylate synthase (ts), dihydrofolate reductase (dhfr), antifolates, classical, nonclassical, inhibitors
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