Current Drug Targets - Cardiovascular & Hematological Disorders

Garry X. Shen
University of Manitoba
Winnipeg, MB
Canada

Back

Snake Venom Prothrombin Activators Similar to Blood Coagulation Factor Xa

Author(s): Jeremiah S. Joseph, R. Manjunatha Kini.

Abstract:

Activation of prothrombin to mature thrombin in vivo occurs by the proteolytic action of the prothrombinase complex consisting of serine proteinase factor Xa, and cofactors that include factor Va, Ca2+ ions and phospholipids. Several exogenous prothrombin activators are found in snake venom. Among these, Group C prothrombin activators resemble the factor Xa-factor Va complex, while Group D activators are structurally and functionally similar to factor Xa. This review provides a detailed description of current knowledge on Group D prothrombin activators and highlights the importance of studying this family of proteins in enhancing our understanding of structure-function relationships in the mammalian prothrombinase complex.

Keywords: snake venom, factor xa, prothrombinase complex, prothrombin activator, anticoagulant, blood clotting, serine proteinase, trocarin d, hopsarin d, notecarin d

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 4
ISSUE: 4
Year: 2004
Page: [397 - 416]
Pages: 20
DOI: 10.2174/1568006043335781
Price: $58