L-Arginine Transport in Disease

Author(s): Antonio Claudio Mendes Ribeiro, Tatiana M. C. Brunini.

Journal Name: Current Medicinal Chemistry - Cardiovascular & Hematological Agents

Volume 2 , Issue 2 , 2004

Submit Manuscript
Submit Proposal


The importance of membrane transport in normal physiological cell function is unquestionable. However, to what extent alterations in the transport of amino acids are the cause and / or consequence of pathological changes observed in disease states is a question not yet completely clarified. Kinetic experiments with blood cells provide a simple and useful model for researching alterations in amino acid transport. The cationic amino acid L-arginine is the precursor of nitric oxide (NO), a key second messenger involved in functions such as endothelium-dependent vascular relaxation, immune defence and platelet activation. The transport of L-arginine, being rate-limiting for nitric oxide production, is extremely relevant to pathological conditions where NO synthesis and / or actions are affected. The current review provides an overview of L-arginine transport in disease, specifically in uraemia, heart failure, hypertension, diabetes mellitus, septic shock and sickle cell disease.

Keywords: l-arginine, nitric oxide, heart failure, uraemia, hypertension, sepsis, diabetes mellitus, sickle cell disease

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2004
Page: [123 - 131]
Pages: 9
DOI: 10.2174/1568016043477288
Price: $58

Article Metrics

PDF: 3