The Oxazolomycins: A Structurally Novel Class of Bioactive Compounds

Author(s): Mark G. Moloney, Paul C. Trippier, Muhammad Yaqoob, Zhaoyang Wang.

Journal Name: Current Drug Discovery Technologies

Volume 1 , Issue 3 , 2004

Abstract:

Oxazolomycin, first isolated in 1985, is a novel bioactive compound, exhibiting potent antiviral, antibacterial and cytotoxic activity, and is now known to be the parent of a wider class of compounds. The broad-spectrum activity of oxazolomycin has been attributed to its protonophoric properties. This review outlines the isolation, structural determination, biosynthesis, bioactivity, biological mode of action and synthesis of all members of this compound class. Significantly, the oxazolomycins appear to offer not only a completely novel chemotype as a bioactive lead structure, but also a chemotype, which also exhibits an unusual biological mode of action.

Keywords: Oxazolomycins, chemotype, protonophoric

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Article Details

VOLUME: 1
ISSUE: 3
Year: 2004
Page: [181 - 199]
Pages: 19
DOI: 10.2174/1570163043334974
Price: $58

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