Current Proteomics

Bernd Rehm  
Institute of Molecular BioSciences Massey University
Private Bag 11222
Palmerston North
New Zealand

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The Computational Versatility of Proteomic Signaling Networks

Author(s): Herbert M. Sauro.

Abstract:

Almost all proteomic signaling networks in prokaryotes and eukaryotes are based on the simple phosphorylation / dephosporylation cycle; from this simple unit it is possible to construct a huge variety of control and computational circuits, both analog and digital. With the characterization of many signaling networks, researchers are turning to address the question of how a particular physiological response can be understood in terms of the proteins that make up the network; this is one of the central questions in “Systems Biology”. In this article I wish to summarize the great versatility of the basic protein cycle as a means to construct complex functional behaviors including the central role that feedback plays in determining the properties of protein based networks.

Keywords: Proteomic Signaling, prokaryotes, eukaryotes

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2004
Page: [67 - 81]
Pages: 15
DOI: 10.2174/1570164043488315