Abstract
We describe how knowledge of three dimensional protein structure can add to the understanding of as yet functionally unannotated protein sequences. Structure determination may reveal that the new protein shares structural similarity with a previously observed structure or that it is a novel fold. The manner in which structure can be used to suggest the function of a protein will depend on the number and diversity of homologous sequences and the extent to which these sequences are functionally characterized. These factors are discussed with reference to a number of illustrative examples of structures solved by structural genomics initiatives.
Keywords: protein, genomics, homologous
Current Proteomics
Title: Structural Proteomics: Inferring Function from Protein Structure
Volume: 1 Issue: 1
Author(s): David L. Wild and Mansoor A. S. Saqi
Affiliation:
Keywords: protein, genomics, homologous
Abstract: We describe how knowledge of three dimensional protein structure can add to the understanding of as yet functionally unannotated protein sequences. Structure determination may reveal that the new protein shares structural similarity with a previously observed structure or that it is a novel fold. The manner in which structure can be used to suggest the function of a protein will depend on the number and diversity of homologous sequences and the extent to which these sequences are functionally characterized. These factors are discussed with reference to a number of illustrative examples of structures solved by structural genomics initiatives.
Export Options
About this article
Cite this article as:
Wild L. David and Saqi A. S. Mansoor, Structural Proteomics: Inferring Function from Protein Structure, Current Proteomics 2004; 1 (1) . https://dx.doi.org/10.2174/1570164043488234
DOI https://dx.doi.org/10.2174/1570164043488234 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
Call for Papers in Thematic Issues
Mass spectrometry data acquisition and analysis for proteomics
The Thematic Issue on "Mass spectrometry data acquisition and analysis for proteomics" aims to explore the latest advancements and challenges in the field of proteomics through the lens of mass spectrometry. Proteomics, the large-scale study of proteins and their functions, plays a crucial role in understanding various biological processes and ...read more
Peptides: State-of-Art and Commercialisation Hurdles
The Editors of the Current Proteomics (CP) journal are highly privileged to welcome scientists to submit their scientific research and review articles to be considered for publication in the upcoming thematic issue. The topics should cover various aspects of peptides in regard to their synthetic methodologies, formulation approaches, pharmacological challenges, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Angiogenin as a Molecular Target for the Treatment of Prostate Cancer
Current Cancer Therapy Reviews Rapid Nucleic Acid Reaction Circuits for Point-of-care Diagnosis of Diseases
Current Topics in Medicinal Chemistry Current Status of Some Antituberculosis Drugs and the Development of new Antituberculous Agents with Special Reference to their In Vitro and In Vivo Antimicrobial Activities
Current Pharmaceutical Design Clinical Application of Percutaneous Puncture Biopsy Guided by Fused and 3D-reconstructed PET/CT Images
Current Medical Imaging Combating Diseases with Computational Strategies Used for Drug Design and Discovery
Current Topics in Medicinal Chemistry Targeting Tumor Necrosis Factor-α in the Therapy of Psoriasis
Current Drug Targets - Inflammation & Allergy Design and Synthesis of (<i>E</i>)-4-(2-Phenyl-2<i>H</i>-chromen-3-yl)but-3-en-2-ones and Evaluation of their <i>In Vitro</i> Antimicrobial Activity
Letters in Organic Chemistry Biosurfactants as a Novel Additive in Pharmaceutical Formulations: Current Trends and Future Implications
Current Drug Metabolism Large Porous Hollow Particles: Lightweight Champions of Pulmonary Drug Delivery
Current Pharmaceutical Design Tetraoxanes as Antimalarials: Harnessing the Endoperoxide
Mini-Reviews in Medicinal Chemistry Therapeutic Nucleic Acids
Recent Patents on Regenerative Medicine Autophagy as a Potential Therapeutic Target in Breast Cancer Treatment
Current Cancer Drug Targets New Insights for Multifactorial Disease Therapy: The Challenge of the Symbiotic Drugs
Current Drug Therapy Pharmacometrics in Dose Finding or Dose Optimization of Anti-Retroviral and Anti-Tubercular Drugs
Infectious Disorders - Drug Targets Aqua Mediated Synthesis of Bio-active Compounds
Mini-Reviews in Medicinal Chemistry Identification of Novel Cytotoxic T Lymphocyte Epitopes of Drug- Resistance Related Protein InhA from Mycobacterium tuberculosis
Protein & Peptide Letters Genetic Diversity of Human SP-A, a Molecule with Innate host Defense and Surfactant-Related Functions; Characteristics, Primary Function, and Significance
Current Pharmacogenomics Nanomedicines as Therapeutics in HIV-AIDS
Pharmaceutical Nanotechnology Current Advances in the Identification and Characterization of Putative Drug and Vaccine Targets in the Bacterial Genomes
Current Topics in Medicinal Chemistry Microwave-Assisted Synthesis of Pyrazinamide Derivatives: The Coupling Reaction of 3-Chloropyrazine-2-Carboxamide and Ring-Substituted Anilines
Current Organic Synthesis