Current Drug Target -CNS & Neurological Disorders

Stephen D. Skaper
Department of Pharmaceutical and Pharmacological Sciences
University of Padova


5-HT2 Receptors

Author(s): J E Leysen

Affiliation: Janssen Pharmaceutica,N.V., Turnhoutseweg, 30, B-2340 Beerse, Belgium.


5-HT2 receptors are G-protein coupled receptors that currently comprise threesubtypes: 5-HT2A, 5-HT2B and 5-HT2C receptors. The subtypes are related in theirmolecular structure, amino acid sequence and signaling properties. 5-HT2A and 5-HT2Creceptors have a widespread distribution and function in the central nervous system.5-HT2A and 5-HT2C receptor antagonism is a property of certain antipsychotic and antidepressantdrugs. 5-HT2B receptors have a restricted expression in the central nervous system. They have animportant role in embryogenesis and in the periphery. In this article, selected aspects of 5-HT2 receptor researchare reviewed for each subtype under three main headings : (i) genes, protein structure and receptor signaling;(ii) receptor localization with emphasisontheCNSand(iii)compounds. Thegeneraldiscussion reflects on the reasons for the limited success in the clinic of 5-HT2 receptor subtypeselective drugs.

Keywords: 5-HT2 Receptors, emphasisontheCNSand

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Article Details

Page: [11 - 26]
Pages: 16
DOI: 10.2174/1568007043482598