Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents

Bahar Tunctan
Department of Pharmacology
Faculty of Pharmacy
Mersin University
Mersin, 33169
Turkey

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Protein-based Strategies of Molecular Therapy in Allergy

Author(s): Katarzyna Grzela, Maciej Lazarczyk, Tomasz Grzela.

Abstract:

The increasing knowledge concerning pathomechanism of hypersensitivity reactions enabled development of new strategies of allergy treatment. Since the molecular background of allergy includes some, still poorly defined, abnormalities in immunoregulatory cytokines network, the successful treatment should restore proper cytokine balance. Therefore, numerous studies concerning administration of missing cytokines or inhibition of excessive one have been undertaken. The possibilities to use IgE- and cytokine-neutralizing antibodies as well as soluble cytokine receptors are discussed in this review. Moreover, attempts to create various mutant cytokines that competitively block cytokine-receptor binding have been detaily described. Although majority of clinical trials analyzing those novel treatment approaches are not finished yet, the evaluation of their preliminary results suggests potential clinical usefulness of such treatment. Obviously, these molecular methods still require further studies, nevertheless, they could be considered as novel standard in allergy treatment pretty soon.

Keywords: allergy, blocking antibodies, mutant cytokines, soluble cytokine receptors

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Article Details

VOLUME: 3
ISSUE: 1
Year: 2004
Page: [53 - 62]
Pages: 10
DOI: 10.2174/1568014043483616