Inhibitors of Mycothiol-S-Conjugate Amidase and Related Genes

Author(s): G. M. Nicholas, C. A. Bewley.

Journal Name: Current Medicinal Chemistry - Anti-Infective Agents
Continued as Anti-Infective Agents

Volume 3 , Issue 3 , 2004


Mycothiol is a small molecular weight thiol exclusive to actinomycetes, a subgroup of Gram-positive bacteria. Mycothiol is composed of one unit each of 1-D-glucosamine, 1-D-myo-inositol and N-acetyl cysteine. Novel enzymes involved in mycothiol biosynthesis, mycothiol-mediated detoxification, and mycothiol reduction have recently been identified, and several of these share little or no sequence homology to known mammalian enzymes. Together, these points suggest that targeting of mycothiol-associated biochemistry may be a valid approach to identifying new types of antibiotics specific to actinomycetes, which include the medically important mycobacteria. This review discusses mycothiol literature to date, with emphasis on chemical approaches to identifying and synthesizing inhibitors and chemical probes to study mycothiol biochemistry.

Keywords: marine natural products, substrate-based inhibitors, mycobacterium tuberculosis, mycobacterium smegmatis, antituberculars, structural studies

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2004
Page: [221 - 231]
Pages: 11
DOI: 10.2174/1568012043353865
Price: $58

Article Metrics

PDF: 2