Recent Advances in the Understanding of HIV-1 Vpu Accessory Protein Functions

Author(s): Julie Binette, Eric A. Cohen.

Journal Name: Current Drug Targets - Immune, Endocrine & Metabolic Disorders

Volume 4 , Issue 4 , 2004

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HIV-1 encodes a number of accessory proteins, which are not commonly found in other retroviruses. These proteins, which include Vif, Vpr, Vpu and Nef, act as multifunctional adapters capable of recruiting and modulating basic host cell processes to optimize wide-ranging aspects of viral replication. This review describes our current understanding of how the Vpu accessory protein functions to modulate HIV-1 particle release and CD4 receptor expression during HIV-1 infection and underlines the potential opportunities afforded by this viral protein for therapeutic intervention.

Keywords: hiv-1, vpu, cd4 degradation, viral release, viral spread

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Article Details

Year: 2004
Page: [297 - 307]
Pages: 11
DOI: 10.2174/1568005310404040297
Price: $58