Recent Advances in the Understanding of HIV-1 Vpu Accessory Protein Functions

Title: Recent Advances in the Understanding of HIV-1 Vpu Accessory Protein Functions

Volume: 4 Issue: 4

Author(s): Julie Binette and Eric A. Cohen

Affiliation:

Keywords: hiv-1, vpu, cd4 degradation, viral release, viral spread

Abstract: HIV-1 encodes a number of accessory proteins, which are not commonly found in other retroviruses. These proteins, which include Vif, Vpr, Vpu and Nef, act as multifunctional adapters capable of recruiting and modulating basic host cell processes to optimize wide-ranging aspects of viral replication. This review describes our current understanding of how the Vpu accessory protein functions to modulate HIV-1 particle release and CD4 receptor expression during HIV-1 infection and underlines the potential opportunities afforded by this viral protein for therapeutic intervention.

Cite this article as:

Binette Julie and Cohen A. Eric, Recent Advances in the Understanding of HIV-1 Vpu Accessory Protein Functions, Current Drug Targets - Immune, Endocrine & Metabolic Disorders 2004; 4 (4) . https://dx.doi.org/10.2174/1568005310404040297