Trafficking Potentials of Unconventional T Cell Subsets

Author(s): Chang H. Kim, Robert Johnson.

Journal Name:Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents

Volume 3 , Issue 4 , 2004


Conventional TCR-αβ T cells dramatically change the expression pattern of homing receptors at least twice during their development to effector T cells. The first change to emigrate out of the thymus and into secondary lymphoid tissues occurs in the thymus. The second change from naïve type to memory type occurs during T cell priming with antigens in secondary lymphoid tissues. Antigen presenting cells and cytokines play critical roles in the switch of homing behavior. However, the two unconventional T cell subsets, CD1d-restricted NKT cells and γδ T cells, are very different from conventional T cells in this respect. NKT cells and γδ T cells display the memory type migration phenotype as soon as they emigrate out of the thymus. This implies that these unconventional T cells do not need to migrate to secondary lymphoid tissues in order to acquire the migratory capacity to non-lymphoid tissues. In this regard, most CD1d-restricted NKT cells and γδ T cells are somewhat similar to polarized conventional effector T cells such as T helper 1 cells and NK cells in their migratory capacity. CD4+CD25+ regulatory T cells, however, are heterogeneous in their homing capacity in a manner similar to the conventional TCR-αβ T cells. Some CD4+CD25+ T cells have the migratory behavior of naïve T cells, while others have the homing capacity of memory T cells. The importance of these migration behaviors of unconventional T cells is discussed in this review.

Keywords: unconventional t cells, nkt cells, t cells, homing receptors, migration, chemokines

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Article Details

Year: 2004
Page: [321 - 330]
Pages: 10
DOI: 10.2174/1568014043355267
Price: $58