The Possible Therapeutic Actions of Peroxisome Proliferator-Activated Receptor α(PPARα) Agonists,PPARγ Agonists,3-Hydroxy-3- Methylglutaryl Coenzyme A (HMG-CoA)Reductase Inhibitors,Angiotensin Converting Enzyme (ACE)Inhibitors and Calcium (Ca)-Antagonists on Vascular Endothelial Cells

Author(s): Ikuo Inoue, Shigehiro Katayama.

Journal Name:Current Drug Targets - Cardiovascular & Hematological Disorders

Volume 4 , Issue 1 , 2004

Abstract:

Several intervention studies have shown that some hypolipidemic and hypotensive drugs such as fibrates,3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)reductase inhibitors,angiotensin converting enzyme (ACE)inhibitors and calcium (Ca)-antagonists prevent atherosclerosis.The main pathological findings in atherosclerosis include abnormal reactions of neutrophils,lymphocytes and monocytes / macrophages,vascular smooth muscle cells and vascular endothelial cells,and the accumulation of cholesterol ester in the arterial wall.Therefore,investigating the effects of these drugs on the arterial wall may improve understanding of the mechanisms underlying atherosclerosis.Here,based on recent studies including our own, we describe the relationships between risk factors for atherosclerosis,especially hyperlipidemia and hypertension,and the molecular mechanisms that govern lipid metabolism in the arteries.

Keywords: vascular endothelial cells, ppar, cu, zn superoxide dismutase (cu,zn-sod), nadph oxidase, sterol response element-binding protein-1 (srebp-1), angiotensin II (ang II), ca channels

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Article Details

VOLUME: 4
ISSUE: 1
Year: 2004
Page: [35 - 52]
Pages: 18
DOI: 10.2174/1568006043481329