Current Drug Targets - Inflammation & Allergy

Kurt S Zaenker
Institute of Immunology and Experimental Oncology
University Witten/Herdecke
Stockumerstraße 10
Witten, 58448
Germany

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Chemokines and Chemokine Receptors as Targets in the Therapy of Psoriasis

Author(s): Bernhard Homey.

Abstract:

Chemokines are members of a superfamily of small, cytokine-like, chemotactic proteins that have recently been shown to critically regulate leukocyte trafficking. Accumulating evidence indicates that the chronically relapsing inflammatory skin disease psoriasis represents a T cell-mediated disease. Thus, the understanding of the underlying mechanisms of memory T cell homing to the skin may provide promising targets for the development of novel therapeutics. Here results of recent studies associating chemokines with a psoriatic phenotype and delineating their role in the recruitment of memory T cells to the skin are discussed.

Keywords: chemokines, chemokine receptors, psoriasis, therapy, ccr4, ccr6, cccr10, cxcr3

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Article Details

VOLUME: 3
ISSUE: 2
Year: 2004
Page: [169 - 174]
Pages: 6
DOI: 10.2174/1568010043343840
Price: $58