Current Drug Targets - Cardiovascular & Hematological Disorders

Garry X. Shen
University of Manitoba
Winnipeg, MB
Canada

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Gene Therapy in Peripheral Artery Disease

Author(s): G. Melillo, F. Serino, C. Cirielli, M. C. Capogrossi.

Abstract:

In the last decade, studies of the biological mechanisms underlying angiogenesis, i.e. the development of a new vasculature from pre-existing blood vessels, have suggested a new approach to peripheral obstructive artery disease based on the treatment of ischemic tissues with angiogenic growth factors. As demonstrated by experimental studies in animal models, a therapeutic effect can be reached as the newly formed vascular network, functioning as a biologic by-pass, restores a normal blood supply to the ischemic territories. New techniques of gene therapy proved effective in reaching sustained concentrations of angiogenic factors in the target tissues. This review concerns the pre-clinical background and the results of the early clinical trials of angiogenic gene therapy, which have shown the safety and feasibility of this new approach.

Keywords: angiogenesis, gene therapy, growth factors, peripheral arterial obstructive disease, clinical trial

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2004
Page: [295 - 300]
Pages: 6
DOI: 10.2174/1568006043336023
Price: $58