Current Drug Targets - Cardiovascular & Hematological Disorders

Garry X. Shen
University of Manitoba
Winnipeg, MB


Antioxidants in Peripheral Arterial Disease

Author(s): F. Violi, L. Loffredo, A. Marcoccia.


Peripheral arterial disease (PAD) is an important manifestation of systemic atherosclerosis that is characterized by obstruction of the arteries in the lower limbs. Experimental and epidemiological studies suggest a key role for oxidative stress in initiation and progression of the atherosclerotic process. The results of these studies provided a good basis for interventional trials with antioxidants, particularly with vitamin E, but the findings were conflicting. In this paper we review the observational and interventional studies with antioxidants, and ask whether vitamin supplementation should be recommended for PAD patients.

Keywords: peripheral arterial disease, oxidative stress, antioxidants, atherosclerosis

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Year: 2004
Page: [289 - 294]
Pages: 6
DOI: 10.2174/1568006043336212
Price: $58