Anti-IgE Therapy in Allergic Asthma

Author(s): Claudia Rolinck-Werninghaus, Ulrich Wahn, Eckard Hamelmann.

Journal Name: Current Drug Targets - Inflammation & Allergy

Volume 4 , Issue 5 , 2005

Abstract:

Despite the advanced and increasing understanding of the pathophysiology of asthma and other allergic diseases, current treatment remains unspecific and targets late events within the allergic cascade. Therefore, a novel and promising approach to treat allergic asthma is antagonizing IgE by anti-IgE antibodies. This review analyzes the role of IgE for the pathology of asthma, summarize the current data about action, safety and efficacy of anti-IgE therapy, and tries to give a rational approach for future indications and directions of treatment with anti-IgE antibodies.

Keywords: asthma, atopy, allergic rhinitis, anti-Ige, monoclonal antibody, treatment

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Article Details

VOLUME: 4
ISSUE: 5
Year: 2005
Page: [551 - 564]
Pages: 14
DOI: 10.2174/156801005774322162
Price: $58

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