Growth Factor Treatment of Stroke

Author(s): Jing Mei Ren, Seth P. Finklestein.

Journal Name: Current Drug Targets - CNS & Neurological Disorders
Continued as CNS & Neurological Disorders - Drug Targets

Volume 4 , Issue 2 , 2005


This review discusses the potential usefulness of several selected polypeptide growth factors as treatments for stroke. Distinctions between global vs. focal cerebral ischemia, permanent vs. temporary focal ischemia, and acute stroke vs. stroke recovery are first discussed. Potential routes of administration of growth factors are also considered. The growth factors basic fibroblast growth factor (bFGF), osteogenic protein-1 (OP- 1), vascular endothelial growth factor (Veg-f), erythropoietin (EPO), and granulocyte colony stimulating factor (G-CSF) all show potential usefulness in animal models of acute stroke and stroke recovery. Two of these factors, bFGF and EPO, have reached human clinical trials for acute stroke, and the data are discussed. Future directions in this field are also discussed.

Keywords: growth factors, cerebral ischemia, stroke, stroke recovery

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Article Details

Year: 2005
Page: [121 - 125]
Pages: 5
DOI: 10.2174/1568007053544101
Price: $58

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