Abstract
CDK2 is an attractive target for the design of new therapeutic antitumor agent. Numerous CDK2 inhibitors have been discovered and their crystallographic structures either in complex with CDK2 or CDK2/Cyclin A have been published. This review aims to summarize the publicly available structural characterization of CDK2/(Cyclin A) - ligand complexes and to highlight the similarities among the binding modes of structurally diverse inhibitors.
Keywords: cyclin-dependent kinase, cdk, x-ray, cell cycle, crystal structure, binding mode, adenine scaffold, adenine mimics
Current Medicinal Chemistry - Anti-Cancer Agents
Title: An Analysis of the Binding Modes of ATP-Competitive CDK2 Inhibitors as Revealed by X-Ray Structures of Protein-Inhibitor Complexes
Volume: 5 Issue: 5
Author(s): A. Vulpetti and P. Pevarello
Affiliation:
Keywords: cyclin-dependent kinase, cdk, x-ray, cell cycle, crystal structure, binding mode, adenine scaffold, adenine mimics
Abstract: CDK2 is an attractive target for the design of new therapeutic antitumor agent. Numerous CDK2 inhibitors have been discovered and their crystallographic structures either in complex with CDK2 or CDK2/Cyclin A have been published. This review aims to summarize the publicly available structural characterization of CDK2/(Cyclin A) - ligand complexes and to highlight the similarities among the binding modes of structurally diverse inhibitors.
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Cite this article as:
Vulpetti A. and Pevarello P., An Analysis of the Binding Modes of ATP-Competitive CDK2 Inhibitors as Revealed by X-Ray Structures of Protein-Inhibitor Complexes, Current Medicinal Chemistry - Anti-Cancer Agents 2005; 5 (5) . https://dx.doi.org/10.2174/1568011054866928
DOI https://dx.doi.org/10.2174/1568011054866928 |
Print ISSN 1568-0118 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5968 |
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