Abstract
A central obstacle to the design of a global HIV vaccine is viral diversity. Antigenic differences in envelope proteins result in distinct HIV serotypes, operationally defined such that antibodies raised against envelope molecules from one serotype will not bind envelope molecules from a different serotype. The existence of serotypes has presented a similar challenge to vaccine development against other pathogens. In such cases, antigenic diversity has been addressed by vaccine design. For example, the poliovirus vaccine includes three serotypes of poliovirus, and Pneumovax(ρ) presents a cocktail of 23 pneumococcal variants to the immune system. It is likely that a successful vaccine for HIV must also comprise a cocktail of antigens. Here, data relevant to the development of cocktail vaccines, designed to harness diverse, envelope-specific Bcell and T-cell responses, are reviewed.
Keywords: hiv envelope protein, cocktail, breadth
Current HIV Research
Title: HIV Vaccine Rationale, Design and Testing
Volume: 3 Issue: 2
Author(s): Robert E. Sealy, Julia L. Hurwitz, Louis N. Martin, James L. Blanchard, Peter C. Doherty, Pamela J. Freiden, Timothy D. Lockey, Brita Brown, John Stambas, Karen S. Slobod, Bart G. Jones, Amy Zirkel, Sherri Surman, Xiaoyan Zhan, Scott A. Brown, Mattia Bonsignori and Chris Coleclough
Affiliation:
Keywords: hiv envelope protein, cocktail, breadth
Abstract: A central obstacle to the design of a global HIV vaccine is viral diversity. Antigenic differences in envelope proteins result in distinct HIV serotypes, operationally defined such that antibodies raised against envelope molecules from one serotype will not bind envelope molecules from a different serotype. The existence of serotypes has presented a similar challenge to vaccine development against other pathogens. In such cases, antigenic diversity has been addressed by vaccine design. For example, the poliovirus vaccine includes three serotypes of poliovirus, and Pneumovax(ρ) presents a cocktail of 23 pneumococcal variants to the immune system. It is likely that a successful vaccine for HIV must also comprise a cocktail of antigens. Here, data relevant to the development of cocktail vaccines, designed to harness diverse, envelope-specific Bcell and T-cell responses, are reviewed.
Export Options
About this article
Cite this article as:
Sealy E. Robert, L. Hurwitz Julia, N. Martin Louis, L. Blanchard James, C. Doherty Peter, J. Freiden Pamela, D. Lockey Timothy, Brown Brita, Stambas John, Slobod S. Karen, Jones G. Bart, Zirkel Amy, Surman Sherri, Zhan Xiaoyan, Brown A. Scott, Bonsignori Mattia and Coleclough Chris, HIV Vaccine Rationale, Design and Testing, Current HIV Research 2005; 3 (2) . https://dx.doi.org/10.2174/1570162053506928
DOI https://dx.doi.org/10.2174/1570162053506928 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Anti-Hormonal Therapies for Premenopausal Patients – What did we Learn from the TEXT/SOFT Trials?
Reviews on Recent Clinical Trials Perspectives of New Therapies for Endometriosis
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Pulmonary Embolism Response Team (PERT) - A New Paradigm for the Treatment of Pulmonary Embolism
Current Pharmaceutical Design Mucoadhesive Polymers for Oral Transmucosal Drug Delivery: A Review
Current Pharmaceutical Design Food and Food Supplements with Hypocholesterolemic Effects
Recent Patents on Food, Nutrition & Agriculture Role of Lymphadenectomy in Endometrial Cancer
Current Women`s Health Reviews Management of Endometrial Cancer: A Review
Reviews on Recent Clinical Trials Stem Cell Function, Self-Renewal, Heterogeneity, and Regenerative Potential in Skeletal Muscle Stem Cells
Recent Patents on Regenerative Medicine Viral Origins of Human Cancer
Current Medicinal Chemistry Management of Ovarian Cancer In Younger Women
Reviews on Recent Clinical Trials A State-of-the-art Review and Prospective Therapeutic Applications of Prenyl Flavonoids as Chemosensitizers against Antifungal Multidrug Resistance in <i>Candida albicans</i>
Current Medicinal Chemistry Marine Sponges: Potential Sources of New Antimicrobial Drugs
Current Pharmaceutical Biotechnology Menstrual and Reproductive Outcomes Following Uterine Artery Fibroid Embolisation: A Literature Review
Current Women`s Health Reviews Past, Present and Future Strategies of Immunotherapy in Gynecological Malignancies
Current Molecular Medicine Medical Treatment of Hirsutism in Women
Current Medicinal Chemistry Meet Our Editorial Board Member
Current Drug Therapy Comparison of Large Proteomic Datasets
Current Proteomics Transmission and Immunopathogenesis of FIV in Cats as a Model for HIV
Current HIV Research The Metabolic Syndrome and the Relevance of Nutrients for its Onset
Recent Patents on Biotechnology Cranberry for Urinary Tract Infection: From Bench to Bedside
Current Topics in Medicinal Chemistry