Management of Liver Disease in Thalassemia: Main Drug Targets for a Correct Therapy

Author(s): G. C. D. Vecchio, A. Nigro, P. Giordano, D. De Mattia.

Journal Name: Current Drug Targets - Immune, Endocrine & Metabolic Disorders

Volume 5 , Issue 4 , 2005

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Liver disease is the second cause of mortality in thalassemia major. We present a review on the hepatic damage in thalassemic patients aimed at a knowledge of current preventive, diagnostic and therapeutic approaches, useful to guide in clinical judgment and treatment decisions. Transfusion related iron overload and hepatitis are the causes of liver damage in thalassemic patients. We examined means of primary prevention, anti-hepatitis vaccinations, blood donors screening; diagnostic tests for secondary prevention (computed tomography, magnetic resonance imaging, super conducting quantum interference device and biopsy) were also discussed about. A survey of treatment methods and strategies ( chelation therapy, antiviral treatments and liver and bone marrow transplantation) follows.

Keywords: Thalassemia, liver disease, iron overload, HCV infection

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Article Details

Year: 2005
Page: [373 - 378]
Pages: 6
DOI: 10.2174/1568005310505040373
Price: $58