Development of Prodrugs for Enzyme-Mediated, Tumor-Selective Therapy

Author(s): K. Jin Yoon , Philip M. Potter , Mary K. Danks .

Journal Name: Current Medicinal Chemistry - Anti-Cancer Agents

Volume 5 , Issue 2 , 2005


Anticancer enzyme / prodrug approaches to therapy are designed to activate prodrugs specifically at tumor loci, to achieve antitumor responses with minimal toxicity. The equivocal success of these approaches thus far has led to searches for more efficient combinations. This mini-review evaluates and compares characteristics of seven selected enzyme / prodrug combinations, and discusses goals for future development of effective combinations.

Keywords: enzyme prodrug therapy, hsv-tk gcv, Herves Simplex Virus-Thymidine Kinase Ganciclovir, cd 5-fc, cytosine deaminase 5-fluorocytosine, pnpase 2-f-araa, purine nucleoside phosphorylase 2-fluoroarabinosyl adenine

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Article Details

Year: 2005
Page: [107 - 113]
Pages: 7
DOI: 10.2174/1568011053174837
Price: $58