Current Medicinal Chemistry - Anti-Cancer Agents

Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Monoclonal Antibody-Based Targeted Therapy in Breast Cancer

Author(s): Kadri Altundag, Francisco J. Esteva, Banu Arun.

Abstract:

Advances in molecular biology have identified tumor markers that not only predict prognosis and therapeutic response but may also function as potential therapeutic targets. Activated growth factor receptors induce breast cancer cells to proliferate, invade, and metastasize in experimental models. Overexpression of growth factor receptors has been associated with a poor clinical outcome in breast cancer patients. Biological therapy with monoclonal antibody directed against growth factor receptor pathways became important targeted therapy in breast cancer and is being pursued on various fronts. The anti-HER2 antibody trastuzumab is approved in the metastatic setting and is now trying to find the place in the adjuvant setting. Phase II and III studies with antibodies directed against VEGF and EGFR are also ongoing.

Keywords: breast cancer, biological therapy, egfr, her-2, monoclonal antibodies

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2005
Page: [99 - 106]
Pages: 8
DOI: 10.2174/1568011053174846
Price: $58