Abstract
Ribozymes and small interfering RNAs (siRNAs) as well as non-natural RNA molecules, such as aptamers, can be used for detection and modulation of gene function at RNA and protein levels. These technologies provide overlapping and complementary methods to antibody-based protein detection. Functional RNAs offer easy to design and simple tools for understanding the function of genes and their products and have potential as therapeutic agents. We review here the advances made with functional RNAs, and illustrate their promise as tools for both in vitro and in vivo proteomic studies.
Keywords: rna, proteomics
Current Proteomics
Title: Functional RNAs as Tools in Proteomics
Volume: 2 Issue: 2
Author(s): N. K. Vaish and S. Zinnen
Affiliation:
Keywords: rna, proteomics
Abstract: Ribozymes and small interfering RNAs (siRNAs) as well as non-natural RNA molecules, such as aptamers, can be used for detection and modulation of gene function at RNA and protein levels. These technologies provide overlapping and complementary methods to antibody-based protein detection. Functional RNAs offer easy to design and simple tools for understanding the function of genes and their products and have potential as therapeutic agents. We review here the advances made with functional RNAs, and illustrate their promise as tools for both in vitro and in vivo proteomic studies.
Export Options
About this article
Cite this article as:
Vaish K. N. and Zinnen S., Functional RNAs as Tools in Proteomics, Current Proteomics 2005; 2 (2) . https://dx.doi.org/10.2174/1570164054494190
DOI https://dx.doi.org/10.2174/1570164054494190 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
Call for Papers in Thematic Issues
Mass spectrometry data acquisition and analysis for proteomics
The Thematic Issue on "Mass spectrometry data acquisition and analysis for proteomics" aims to explore the latest advancements and challenges in the field of proteomics through the lens of mass spectrometry. Proteomics, the large-scale study of proteins and their functions, plays a crucial role in understanding various biological processes and ...read more
Peptides: State-of-Art and Commercialisation Hurdles
The Editors of the Current Proteomics (CP) journal are highly privileged to welcome scientists to submit their scientific research and review articles to be considered for publication in the upcoming thematic issue. The topics should cover various aspects of peptides in regard to their synthetic methodologies, formulation approaches, pharmacological challenges, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Pentoxifylline and Local Honey for Radiation-Induced Burn Following Breast Conservative Surgery
Current Clinical Pharmacology The Role of Epigenetics in the Progression of Non-Alcoholic Fatty Liver Disease
Mini-Reviews in Medicinal Chemistry Studies on Non-synonymous Polymorphisms Altering Human DNA Topoisomerase II-Alpha Interaction with Amsacrine and Mitoxantrone: An <i>In Silico</i> Approach
Current Cancer Drug Targets Retinoic Acid and the Gut Microbiota in Alzheimer’s Disease: Fighting Back-to-Back?
Current Alzheimer Research Non-glycemic Adverse Effects of Insulin
Current Diabetes Reviews STAT Signaling and Cell Function
Current Genomics Effect of Alpha-1-Acid Glycoprotein Binding on Pharmacokinetics and Pharmacodynamics
Current Drug Metabolism The Role of Thiols and Disulfides on Protein Stability
Current Protein & Peptide Science Mechanism of Action of Flavonoids in Prevention of Inflammation- Associated Skin Cancer
Current Medicinal Chemistry The Struggle with Rheumatism through Dracunculus vulgaris Schott: In the Light of Ethnobotanical Information
Current Molecular Pharmacology Mast Cell – Glia Dialogue in Chronic Pain and Neuropathic Pain: Blood-Brain Barrier Implications
CNS & Neurological Disorders - Drug Targets Histological and Direct Evidence for the Role of Complement in the Neuroinflammation of AD
Current Alzheimer Research Computational Analysis of Specific IgE Epitopes Responsible for Allergy to Fish
Current Immunology Reviews (Discontinued) Human Interleukin-19: Structure, Function and Disease Associations
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Eph as a Target in Inflammation
Endocrine, Metabolic & Immune Disorders - Drug Targets Pidotimod and Immunological Activation in Individuals Infected with HIV
Current HIV Research Bacterial Protein Mimetic of Peptide Hormone as a New Class of Protein- based Drugs
Current Medicinal Chemistry Eotaxins and CCR3 Receptor in Inflammatory and Allergic Skin Diseases: Therapeutical Implications
Current Drug Targets - Inflammation & Allergy Drug-Induced Pulmonary Hypertension in Newborns: A Review.
Current Vascular Pharmacology BACE1 Structure and Function in Health and Alzheimers Disease
Current Alzheimer Research