Current Proteomics

Bernd Rehm  
Institute of Molecular BioSciences Massey University
Private Bag 11222
Palmerston North
New Zealand

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Toxicoproteomics: Applications in Drug Development

Author(s): N. Gupta, A. Law, R. Poddar, M. Louie, A. Ray, D. N. Chakravarti.

Abstract:

Toxicoproteomics is the study of the effects of chemical exposure on tissues through identification and quantitative evaluation of changes occurring in the proteome profile. This approach has been and continues to be applied in the preclinical testing of drugs for precise as well as high-throughput determination of toxic effects. Several investigations have indicated that use of proteomics can lead to successful identification of potentially toxic compounds earlier in the drug development process. This review covers recent studies that have used simultaneous measurement of multiple protein markers for prediction of tissue toxicities. In addition, conventional and newer proteomic techniques have been evaluated for applicability to drug toxicology studies. The potential of toxicoproteomics to predict adverse drug reactions in clinical use have also been explored.

Keywords: proteomics, toxicoproteomics, drug toxicology, personalized medicine, hepatotoxicity, nephrotoxicity

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2005
Page: [97 - 101]
Pages: 5
DOI: 10.2174/1570164054494181
Price: $58