Preparation of Cherry-Picked Combinatorial Libraries by String Synthesis

Author(s): Arpad Furka, Gabor Dibo, Naran Gombosuren.

Journal Name: Current Drug Discovery Technologies

Volume 2 , Issue 1 , 2005

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Abstract:

String synthesis [1-3] is an efficient and cheap manual method for preparation of combinatorial libraries by using macroscopic solid support units. Sorting the units between two synthetic steps is an important operation of the procedure. The software developed to guide sorting can be used only when complete combinatorial libraries are prepared. Since very often only selected components of the full libraries are needed, new software was constructed that guides sorting in preparation of non-complete combinatorial libraries. Application of the software is described in details.

Keywords: split-mix synthesis, combinatorial libraries, string synthesis, software

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Article Details

VOLUME: 2
ISSUE: 1
Year: 2005
Page: [23 - 27]
Pages: 5
DOI: 10.2174/1570163053175420

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