Thymulin: An Emerging Anti-Inflammatory Molecule

Author(s): J. J. Haddad, N. E. Saade, B. Safieh-Garabedian.

Journal Name:Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents

Volume 4 , Issue 3 , 2005

Abstract:

Thymulin is a neuroendocrine hormone with immunoregulatory actions. Originally known as serum thymic factor (FTS), thymulin binds to a carrier protein and zinc (Zn2+) to exert its biologic properties. Thymulin, albeit an essential hormone for the T lymphocyte differentiation and the normalization of the ratio of T-helper cells to suppressor cells, accumulating evidence suggests its involvement in inflammations of various etiologies. Recently, thymulin has been shown to have anti-nociceptive effects in hyperalgesia and in pain of neurogenic origin, ostensibly through action on sensory afferents and the release of anti-inflammatory mediators. Given its anti-inflammatory potential, thymulin downregulates the release of inflammatory mediators, such as cytokines and chemokines, upregulates anti-inflammatory factors, such as interleukin (IL)-10, and exerts molecular control via the regulation of transcription factors and mediators. Recent evidence tends to indicate that thymulin can be a therapeutic agent in many inflammatory diseases and in pathological conditions affecting the peripheral and/or the central nervous system. This review discusses current concepts in the antiinflammatory actions of thymulin and correlates this activity with an emerging theme for therapeutic treatment.

Keywords: anti-inflammatory, cytokines, immune-therapy, inflammation, neurodegeneration, transcription factors, thymulin

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2005
Page: [333 - 338]
Pages: 6
DOI: 10.2174/1568014054065195
Price: $58