Current Medicinal Chemistry - Anti-Infective Agents

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Recent Progress in the Discovery of New CCR5 and CXCR4 Chemokine Receptor Antagonists as Inhibitors of HIV-1 Entry. Part 2*

Author(s): Wieslaw M. Kazmierski, Jennifer P. Peckham, Maosheng Duan, Terry P. Kenakin, Stephen Jenkinson, Kristjan S. Gudmundsson, Stephen C. Piscitelli, Paul L. Feldman.

Abstract:

This review addresses key medicinal chemistry issues relevant in the discovery and development of CCR5 and CXCR4 antagonists as anti-HIV drugs. Recent progress in the discovery and development of such antagonists, SAR and clinical status are reviewed.

Keywords: chemotherapy, transcriptase inhibitors, aids, ccr5 receptor, probe, chemokine, allosteric modulator

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Article Details

VOLUME: 4
ISSUE: 2
Year: 2005
Page: [133 - 152]
Pages: 20
DOI: 10.2174/1568012053506981
Price: $58