Recent Progress in the Discovery of New CCR5 and CXCR4 Chemokine Receptor Antagonists as Inhibitors of HIV-1 Entry. Part 2*
Wieslaw M. Kazmierski,
Jennifer P. Peckham,
Terry P. Kenakin,
Kristjan S. Gudmundsson,
Stephen C. Piscitelli,
Paul L. Feldman.
This review addresses key medicinal chemistry issues relevant in the discovery and development of CCR5 and CXCR4 antagonists as anti-HIV drugs. Recent progress in the discovery and development of such antagonists, SAR and clinical status are reviewed.
Keywords: chemotherapy, transcriptase inhibitors, aids, ccr5 receptor, probe, chemokine, allosteric modulator
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