Current Drug Targets - Cardiovascular & Hematological Disorders

Garry X. Shen
University of Manitoba
Winnipeg, MB
Canada

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B Cell Tolerance: Lessons from Transplantation

Author(s): Marilia Cascalho.

Abstract:

Given the ability of the B cell compartment to acquire tolerance to self we cannot explain why spontaneous humoral tolerance does not arise following transplantation. Here we review the fundamental mechanisms of B cell tolerance that operate in development and direct the reader to possible mechanisms that may explain how B cell tolerance fails to develop following transplantation

Keywords: b cells, antibodies, tolerance, allotransplantation

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Article Details

VOLUME: 5
ISSUE: 3
Year: 2005
Page: [271 - 275]
Pages: 5
DOI: 10.2174/1568006054064771
Price: $58