Differentiation of CD8 T Cells in Response to Acute and Chronic Viral Infections: Implications for HIV Vaccine Development
J. D. Miller, D. Masopust, E. J. Wherry, S. Kaech, G. Silvestri and R. Ahmed
Pages 121-129 (9)
Successful HIV vaccine strategies will likely require the induction of robust cellular immune responses, in addition to strong humoral responses. Unfortunately, there is no clear molecular definition of an effective HIV-specific CD8 T cell response. In this review, we discuss the differentiation of CD8 T cells in response to acute and chronic viral infections. We then apply concepts derived from these studies to predict the desirable characteristics of HIV-specific CD8 T cell memory.
cd t cells, lcmv, hiv vaccine, differentiation, immune memory
Emory Vaccine Center,Department of Microbiology and Immunology, Department of Medicine,Emory University School of Medicine, Atlanta, GA 30322, USA.