Current Drug Targets - Infectious Disorders

Jean-Marc Sabatier
Laboratoire ERT 62 'Ingénierie des peptides à visée thérapeutique'
Université de la Méditerranée
Faculté de Médecine Nord
Boulevard Pierre Dramard
13916 - MARSEILLE, Cedex 20
France

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Differentiation of CD8 T Cells in Response to Acute and Chronic Viral Infections: Implications for HIV Vaccine Development

Author(s): J. D. Miller, D. Masopust, E. J. Wherry, S. Kaech, G. Silvestri, R. Ahmed.

Abstract:

Successful HIV vaccine strategies will likely require the induction of robust cellular immune responses, in addition to strong humoral responses. Unfortunately, there is no clear molecular definition of an effective HIV-specific CD8 T cell response. In this review, we discuss the differentiation of CD8 T cells in response to acute and chronic viral infections. We then apply concepts derived from these studies to predict the desirable characteristics of HIV-specific CD8 T cell memory.

Keywords: cd t cells, lcmv, hiv vaccine, differentiation, immune memory

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2005
Page: [121 - 129]
Pages: 9
DOI: 10.2174/1568005054201544
Price: $58