Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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cAMP-Mediated Regulation of CYP Enzymes and Its Application in Chemotherapy

Author(s): Yoshihiro Ishikawa, Sayaka Suzuki, Koji Otsu, Coskun Ulucan, Kousaku Iwatsubo, Haruki Eguchi.

Abstract:

Certain anti-cancer prodrugs are subject to cytochrome P450 (CYP)-mediated metabolism and become more active. Because CYP activity may be regulated by phosphorylation via adenylyl cyclase/protein kinase A, selective adenylyl cyclase subtype activators may be utilized in future chemotherapy to regulate CYP activity as a switch in a tumor tissue-specific manner.

Keywords: Cytochrome P450, protein kinase A, adenylyl cyclase, phosphorylation, forskolin, anti-cancer drugs

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Article Details

VOLUME: 1
ISSUE: 3
Year: 2007
Page: [176 - 178]
Pages: 3
DOI: 10.2174/187231207781369744
Price: $58