Antioxidants Suppress Th1-Type Immune Response In Vitro
Inflammation is a hallmark of various diseases like infections, autoimmune syndromes, cardiovascular and neurodegenerative disorders, and cancer. Thereby, Th1-type cytokine interferon-γ is a central pro-inflammatory mediator. Antioxidant compounds counteract the activation of T-cells and macrophages. This anti-inflammatory activity could be important for the development of immunotolerance and for treatment of above-mentioned disorders.
Keywords: Antioxidants, inflammation, neopterin, indoleamine (2,3)-dioxygenase, interferon-γ
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