Current HIV Research

Charles Wood  
University of Nebraska
Lincoln, NE
USA

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HIV-1-Discordant Couples in Sub-Saharan Africa: Explanations and Implications for High Rates of Discordancy

Author(s): Brandon L. Guthrie, Guy de Bruyn and Carey Farquhar

Affiliation: 325 Ninth Avenue, University of Washington Box 359909, Seattle, WA 98104-2499, USA.

Abstract:

In sub-Saharan Africa, approximately 1 in 2 HIV-1-infected persons living in a couple have a serodiscordant partner. Recent data suggest a large proportion of new HIV-1 infections in mature epidemics occur within discordant couples, making discordancy a major contributor to the spread of HIV/AIDS in Africa. What accounts for high rates of HIV-1 discordance and why some individuals remain uninfected despite repeated sexual exposure to HIV-1 is unknown. Studying HIV-1-discordant couples may contribute to understanding correlates of HIV-1 immunity and acute infection. Additionally, HIV-1-discordant couples are an important population for prevention efforts. Consequently, HIV-1-discordant couples are increasingly viewed as a valuable source of participants for HIV vaccine and prevention trials. This review summarizes and critiques existing data on HIV-1-discordant couples in developing countries, including an analysis of transmission rates within discordant couples, description of biological and behavioral characteristics important in planning HIV-1 vaccine and prevention trials, and challenges faced when carrying out such studies.

Keywords: HIV, discordant, couples, Africa, heterosexual transmission

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Article Details

VOLUME: 5
ISSUE: 4
Page: [416 - 429]
Pages: 14
DOI: 10.2174/157016207781023992
Price: $58