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Recent Patents on Biotechnology
ISSN (Print): 1872-2083
ISSN (Online): 2212-4012
VOLUME: 1
ISSUE: 2
DOI: 10.2174/187220807780809436      Price:  $100









Plasmid DNA Manufacturing Technology

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Author(s): Aaron E. Carnes and James A. Williams
Pages 151-166 (16)
Abstract:
Today, plasmid DNA is becoming increasingly important as the next generation of biotechnology products (gene medicines and DNA vaccines) make their way into clinical trials, and eventually into the pharmaceutical marketplace. This review summarizes recent patents and patent applications relating to plasmid manufacturing, in the context of a comprehensive description of the plasmid manufacturing intellectual property landscape. Strategies for plasmid manufacturers to develop or in-license key plasmid manufacturing technologies are described with the endpoint of efficiently producing kg quantities of plasmid DNA of a quality that meets anticipated European and FDA quality specifications for commercial plasmid products.
Keywords:
Plasmid, DNA vaccine, gene therapy, fermentation, purification, alkaline lysis, downstream processing
Affiliation:
Nature Technology Corporation, 4701 Innovation Drive, Lincoln, NE 68521, USA.