Current Proteomics

Bernd Rehm  
Institute of Molecular BioSciences Massey University
Private Bag 11222
Palmerston North
New Zealand


Phosphoproteomics: Challenges and Opportunities

Author(s): Kimberly A. Lee, Gary D. Means, Scott D. Patterson.


Signal transduction through reversible protein phosphorylation plays a central role in cellular physiology in both normal and disease states, and mass spectrometry is well-suited to the task of identifying and cataloging protein phosphorylation sites. Recent advances in sample enrichment strategies, instrumentation, and software availability allow researchers to identify hundreds of phosphorylation sites in a single study. However, to take the next step toward translating these findings into clinical application, the biological relevance of the sites must be validated and clinical assays must be developed to monitor phospho-specific biomarkers.

Keywords: Phosphoproteomics, biomarker discovery, mass spectrometry, Phosflow™

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Article Details

Year: 2006
Page: [249 - 257]
Pages: 9
DOI: 10.2174/157016406780655559
Price: $58