Frequency of CYP1A2 Polymorphism in Beagle Dogs
Valerie J. Whiterock,
Terrye A. Delmonte,
Lester E. Hui,
Tami L. Orcutt,
Michael W. Sinz.
A single nucleotide polymorphism in the dog CYP1A2 gene causes these animals to be CYP1A2 deficient (i.e., lack functional CYP1A2 enzyme activity). Genotyping a colony of 79 dogs revealed 77% wild-type, 19% heterozygous, and 4% homozygous mutant animals. These genetic frequencies are significantly different from those previously reported and illustrate that different sources and populations of dogs can have dramatically different frequencies of this polymorphism.
Keywords: Polymorphism, dog, CYP1A2, frequency, poor metabolizers, pharmacokinetics
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