Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Intracellular Delivery of Nanogel-Quantum Dot Hybrid Nanoparticles into Human Periodontal Ligament Cells

Author(s): Tomoe Fukui, Hiroaki Kobayashi, Urara Hasegawa, Toshiyuki Nagasawa, Kazunari Akiyoshi, Isao Ishikawa.

Abstract:

Nanogels of cholesterol-bearing pullulan modified with amino-groups (CHPNH2) were utilized as a career to introduce quantum dots (QDs) into periodontal ligament (PDL) cells. Nanogel-QD effectively labeled PDL cells over 3 weeks. These results indicate that CHPNH2nanogels have a potential as a research tool in the studies of intracellular delivery system.

Keywords: Periodontal ligament cell, intracellular delivery, nanogel, quantum dot, live cell imaging

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Article Details

VOLUME: 1
ISSUE: 2
Year: 2007
Page: [131 - 135]
Pages: 5
DOI: 10.2174/187231207780363570
Price: $58