Involvement of Cytochromes P450 2D6, 2B6 and 2C19 in the Metabolism of (-)-Deprenyl and N-Methyl,N-propargylphenylethylamine
K. A. Rittenbach,
G. B. Baker.
The metabolism of (-)-deprenyl (N-methyl,N-propargylamphetamine) and N-methyl,N-propargylphenylethylamine (MPPE), monoamine oxidase inhibitors with neuroprotective properties, was studied using human liver microsomes and cDNA-expressed cytochrome P450 (CYP) enzymes. The metabolic pathways of MPPE parallel those of (-)- deprenyl, but some marked differences were observed, particularly with regard to the contributions of CYP2B6 and CYP2D6.
Keywords: amphetamine, CYP2B6, propargylamphetamine, cDNA, Metabolism
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