Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Involvement of Cytochromes P450 2D6, 2B6 and 2C19 in the Metabolism of (-)-Deprenyl and N-Methyl,N-propargylphenylethylamine

Author(s): K. A. Rittenbach, G. B. Baker.

Abstract:

The metabolism of (-)-deprenyl (N-methyl,N-propargylamphetamine) and N-methyl,N-propargylphenylethylamine (MPPE), monoamine oxidase inhibitors with neuroprotective properties, was studied using human liver microsomes and cDNA-expressed cytochrome P450 (CYP) enzymes. The metabolic pathways of MPPE parallel those of (-)- deprenyl, but some marked differences were observed, particularly with regard to the contributions of CYP2B6 and CYP2D6.

Keywords: amphetamine, CYP2B6, propargylamphetamine, cDNA, Metabolism

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Article Details

VOLUME: 1
ISSUE: 2
Year: 2007
Page: [97 - 100]
Pages: 4
DOI: 10.2174/187231207780363589
Price: $58