Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Peroxynitrite Induces Apoptosis and Decline in Intracellular Free Mg with Concomitant Elevation in [Ca2+]i in Rat Aortic Smooth Muscle Cells:Possible Roles of Extracellular and Intracellular Magnesium Ions in Peroxynitrite-Induced Cell Death

Author(s): Jianfeng Li, Wenyan Li, Weimin Liu, Bella T. Altura, Burton M. Altura.

Abstract:

The present study demonstrates that exogenous ONOO- can result in rapid declines in intracellular free magnesium ions ([Mg2+]i) concomitant with rapid rises in intracellular free calcium ions ([Ca2+]i) and, subsequently, trigger apoptosis but not necrosis in rat aortic SMCs; high [Mg2+] significantly attenuates ONOO--induced apoptosis. ONOO-- induced apoptosis in vascular SMCs appears to involve activation of Ca2+-Mg2+-dependent endonucleases and caspase-3. Mg deficiency itself could not induce apoptosis in these SMCs, but it could significantly enhance ONOO-- induced apoptosis.

Keywords: Peroxynitrite, apoptosis, vascular smooth muscle cells, magnesium, rat aorta

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Article Details

VOLUME: 1
ISSUE: 2
Year: 2007
Page: [85 - 89]
Pages: 5
DOI: 10.2174/187231207780363651
Price: $58