Triple Reuptake Inhibitors (“Broad Spectrum” Antidepressants)

Author(s): Phil Skolnick, Anthony S. Basile.

Journal Name: CNS & Neurological Disorders - Drug Targets

Volume 6 , Issue 2 , 2007

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Abstract:

The majority of antidepressants in current use inhibit the uptake of serotonin and/or norepinephrine. Drugs inhibiting the uptake of serotonin, norepinephrine and dopamine (triple reuptake inhibitors) may offer therapeutic advantages compared to single and/or dual reuptake inhibitors. This review provides a rationale for developing this class of compound and describes the results of preclinical and clinical studies with a family of triple reuptake inhibitors.

Keywords: Antidepressant, dopamine, serotonin, norepinephrine, biogenic, amines, depression

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Article Details

VOLUME: 6
ISSUE: 2
Year: 2007
Page: [141 - 149]
Pages: 9
DOI: 10.2174/187152707780363285
Price: $58

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