Prediction of Antigenic Epitopes of Neurotoxin Bmbktx1 from Mesobuthus martensii

Author(s): Virendra S. Gomase.

Journal Name: Current Drug Discovery Technologies

Volume 3 , Issue 3 , 2006

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Abstract:

Gene therapy or recombinant DNA vaccines targeting multiple antigenic components to direct empower the immune system. Antigenic epitopes on neurotoxin Mesobuthus martensii (Buthus martensii) are important determinant of protection against cardiovascular disorder. Small segments 4-YSSDCRVKCVAM-15, 18-SSGKCINSKC-27 of neurotoxin protein called the antigenic epitopes is sufficient for eliciting the desired immune response. In analysis predicted antigenic epitopes neurotoxin protein is seen. Immunization cassettes should be capable of immunizing of broad immunity against both humoral and cellular epitope thus giving vaccines the maximum ability to deal with neurotoxin protein of M. martensii. We have predicted a successful immunization.

Keywords: Neurotoxin, antigenic epitope, GOR, hydrophobicity, hydrophilicity

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2006
Page: [225 - 229]
Pages: 5
DOI: 10.2174/157016306780136817
Price: $58