Advanced Nanotechnological Approaches for Designing Protein-Based “Lab-on-Chips” Sensors on Porous Silicon Wafer
Stefano Borini, Maria Staiano, Massimiliano Rocchia, Andrea M. Rossi, Mose Rossi, Sabato D', ’ and Auria
Affiliation: Istituto di Biochimica delle Proteine, Consiglio Nazionale delle Ricerche, Via Pietro Castellino, 111, 80131 Naples, Italy.
In this article, we will review the more recent patented approaches related to the design and development of micro- and nano-patterns of biomolecules on solid substrates for the realization of innovative biochips, including inkjet and spotting technology, and Scanning Probe Methods In addition, we will report on some important patents based on the use of porous materials as substrates, exploiting the large specific surface for the design of highly sensitive biodevices. The main advantages and drawbacks related to each technological approach to the biochips fabrication will be pointed out, and future perspectives in the field will be discussed.
Keywords: Biosensors, porous silicon, Atomic force microscopy, nanolithography, biochip, bioarray, nanotubes, proteins
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