Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Drug Interactions of Tipranavir, a New HIV Protease Inhibitor

Author(s): Judit Morello, Sonia Rodriguez-Novoa, Inmaculada Jimenez-Nacher, Vincent Soriano.

Abstract:

Tipranavir is one of the latest approved HIV protease inhibitors. This non-peptidic molecule is an strong inducer of cytochrome P450 and has to be co-administered with low doses ritonavir as pharmacokinetic booster to achieve effective antiviral activity in vivo. As expected, significant drug interactions may occur in patients treated with tipranavir/ ritonavir, including diminished exposure to some antiretroviral agents. Although a few interactions can be managed with adequate drug dosing others preclude to use these medications in combination.

Keywords: Tipranavir, HIV, drug interactions, protease inhibitors

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2007
Page: [81 - 84]
Pages: 4
DOI: 10.2174/187231207779814256