Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Effects of Propofol Analogs on Glucuronidation of Propofol, an Anesthetic Drug, by Human Liver Microsomes

Author(s): Makiko Shimizu, Yoshiaki Matsumoto, Hiroshi Yamazaki.

Abstract:

prevent rapid forming O-glucuronide of propofol (2,6-diisopropylphenol), an intravenous anesthetic, effects To of propofol analogs were investigated. Propofol was predominately glucuronidated by human UGT1A9 and intestinal or liver microsomes. 2,5-Diisopropylphenol inhibited the propofol glucuronidation. A possibility of developing orally administrable agents or of reducing propofol dose by coadministration is suggested.

Keywords: Propofol, UGT1A9, inhibitor, glucuronidation, human, 2,5-diisopropylphenol

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2007
Page: [77 - 79]
Pages: 3
DOI: 10.2174/187231207779814355