Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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A Unique Example of Drug Metabolism: Tetra- and Penta-Oxygenation Reactions of Capravirine in Rats, Dogs and Humans

Author(s): Hai-Zhi Bu, William F. Pool, Ellen Y. Wu, Bhasker V. Shetty.

Abstract:

Six tetra- and two penta-oxygenated capravirine metabolites observed in rats, dogs and humans represent the maximum numbers of isomers that can be predicted since oxygenations are restricted at the pyridinyl nitrogen (Noxidation), sulfur (sulfoxidation), and isopropyl group (hydroxylation), exemplifying a unique case that is very unusual for sequential drug metabolism.

Keywords: Capravirine, oxygenation, metabolism, structure elucidation, profiling, identification, biotransformation

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2007
Page: [61 - 65]
Pages: 5
DOI: 10.2174/187231207779814373