Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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A Role for Lysosomal Phospholipase A2 in Drug Induced Phospholipidosis

Author(s): Akira Abe, Miki Hiraoka, James A. Shayman.

Abstract:

Many therapeutic drugs currently in use are cationic amphiphiles. These cationic amphiphilic drugs (CADs) induce phospholipidosis in humans and experimental animals. The recent study shows that CAD-induced cellular phospholipidosis is linked to the impairment of phospholipid catabolism by inhibition of lysosomal phospholipase A2 activity.

Keywords: Cationic amphiphilic drug, amiodarone, PDMP, tetracycline, phospholipidosis, lysosomal phospholipase A2

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2007
Page: [49 - 53]
Pages: 5
DOI: 10.2174/187231207779814292