A Role for Lysosomal Phospholipase A2 in Drug Induced Phospholipidosis
James A. Shayman.
Many therapeutic drugs currently in use are cationic amphiphiles. These cationic amphiphilic drugs (CADs) induce phospholipidosis in humans and experimental animals. The recent study shows that CAD-induced cellular phospholipidosis is linked to the impairment of phospholipid catabolism by inhibition of lysosomal phospholipase A2 activity.
Keywords: Cationic amphiphilic drug, amiodarone, PDMP, tetracycline, phospholipidosis, lysosomal phospholipase A2
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